Factors influencing nucleo-cytoplasmic trafficking: which matter? Response to Alvisi & Jans' comment on Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights.
نویسندگان
چکیده
The authors respond to a comment by Alvisi & Jans [(2014), Acta Cryst. D70, 2775-2776] on the article Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights [Róna et al. (2013), Acta Cryst. D69, 2495-2505].
منابع مشابه
Comment on Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights by Róna et al. (2013).
The authors comment on the article by Róna et al. [(2013), Acta Cryst. D69, 2495-2505].
متن کاملPhosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights.
Phosphorylation adjacent to nuclear localization signals (NLSs) is involved in the regulation of nucleocytoplasmic transport. The nuclear isoform of human dUTPase, an enzyme that is essential for genomic integrity, has been shown to be phosphorylated on a serine residue (Ser11) in the vicinity of its nuclear localization signal; however, the effect of this phosphorylation is not yet known. To i...
متن کاملDynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation.
Phosphorylation by the cyclin-dependent kinase 1 (Cdk1) adjacent to nuclear localization signals (NLSs) is an important mechanism of regulation of nucleocytoplasmic transport. However, no systematic survey has yet been performed in human cells to analyze this regulatory process, and the corresponding cell-cycle dynamics have not yet been investigated. Here, we focused on the human proteome and ...
متن کاملThe BRCA-1 binding protein BRAP2 is a novel, negative regulator of nuclear import of viral proteins, dependent on phosphorylation flanking the nuclear localization signal.
This study describes for the first time the ability of the novel BRCA1-binding protein 2 (BRAP2) to inhibit the nuclear import of specific viral proteins dependent on phosphorylation. Ectopic expression of BRAP2 in transfected African green monkey kidney COS-7 cells was found to significantly reduce nuclear localization signal (NLS)-dependent nuclear accumulation of either simian virus SV40 lar...
متن کاملSignalling takes control of nucleo-cytoplasmic trafficking. Workshop on signal-regulated nuclear transport.
Regulated transit of macromolecules across the nuclear envelope (NE) is a hallmark of eukaryotic cells, and in the last 10 years basic transport mechanisms have been elucidated. Transport factors of the importin/karyopherin-β (Impβ) superfamily decode nuclear localization signals (NLS) or nuclear export signals (NES) in the amino acid sequence of proteins and chaperone them through the nuclear ...
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ورودعنوان ژورنال:
- Acta crystallographica. Section D, Biological crystallography
دوره 70 Pt 10 شماره
صفحات -
تاریخ انتشار 2014